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BibTeX
Serine/threonine‐protein kinase D2‐mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression
The Journal of pathology, 2024-05, Vol.263 (1), p.99-112
Liu, Yin‐Qiao
Xu, Yi‐Wei
Zheng, Zheng‐Tan
Li, Die
Hong, Chao‐Qun
Dai, Hao‐Qiang
Wang, Jun‐Hao
Chu, Ling‐Yu
Liao, Lian‐Di
Zou, Hai‐Ying
Li, En‐Min
Xie, Jian‐Jun
Fang, Wang‐Kai
2024
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Liu, Yin‐Qiao
Xu, Yi‐Wei
Zheng, Zheng‐Tan
Li, Die
Hong, Chao‐Qun
Dai, Hao‐Qiang
Wang, Jun‐Hao
Chu, Ling‐Yu
Liao, Lian‐Di
Zou, Hai‐Ying
Li, En‐Min
Xie, Jian‐Jun
Fang, Wang‐Kai
Titel
Serine/threonine‐protein kinase D2‐mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression
Ist Teil von
The Journal of pathology, 2024-05, Vol.263 (1), p.99-112
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2024
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Desmoglein‐2 (DSG2) is a transmembrane glycoprotein belonging to the desmosomal cadherin family, which mediates cell–cell junctions; regulates cell proliferation, migration, and invasion; and promotes tumor development and metastasis. We previously showed serum DSG2 to be a potential biomarker for the diagnosis of esophageal squamous cell carcinoma (ESCC), although the significance and underlying molecular mechanisms were not identified. Here, we found that DSG2 was increased in ESCC tissues compared with adjacent tissues. In addition, we demonstrated that DSG2 promoted ESCC cell migration and invasion. Furthermore, using interactome analysis, we identified serine/threonine‐protein kinase D2 (PRKD2) as a novel DSG2 kinase that mediates the phosphorylation of DSG2 at threonine 730 (T730). Functionally, DSG2 promoted ESCC cell migration and invasion dependent on DSG2‐T730 phosphorylation. Mechanistically, DSG2 T730 phosphorylation activated EGFR, Src, AKT, and ERK signaling pathways. In addition, DSG2 and PRKD2 were positively correlated with each other, and the overall survival time of ESCC patients with high DSG2 and PRKD2 was shorter than that of patients with low DSG2 and PRKD2 levels. In summary, PRKD2 is a novel DSG2 kinase, and PRKD2‐mediated DSG2 T730 phosphorylation promotes ESCC progression. These findings may facilitate the development of future therapeutic agents that target DSG2 and DSG2 phosphorylation. © 2024 The Pathological Society of Great Britain and Ireland.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.6264
Titel-ID: cdi_proquest_miscellaneous_2932438256
Format
–
Schlagworte
AKT protein
,
Cell adhesion & migration
,
Cell junctions
,
Cell Line, Tumor
,
Cell migration
,
Cell Movement - physiology
,
Cell proliferation
,
Cell Proliferation - physiology
,
Desmoglein 2 - genetics
,
Desmoglein 2 - metabolism
,
DSG2
,
Esophageal cancer
,
Esophageal carcinoma
,
Esophageal Neoplasms - pathology
,
esophageal squamous cell carcinoma
,
Esophageal Squamous Cell Carcinoma - metabolism
,
Gene Expression Regulation, Neoplastic
,
Humans
,
Kinases
,
Metastases
,
migration and invasion
,
Molecular modelling
,
Phosphorylation
,
PRKD2
,
Protein kinase
,
Protein Kinase D2
,
Serine
,
Squamous cell carcinoma
,
Threonine
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