Details

Autor(en) / Beteiligte

• Madiu, Rufai
• Dellosso, Brandon
• Doran, Erin L
• Doran, Jenna M
• Pinarci, Ali A
• TenHoeve, Tyler M
• Howard, Amari M
• Stroud, James L
• Rivera, Dominic A
• Moskovitz, Dylan A
• Finneran, Steven J
• Singer, Alyssa N
• Rossi, Morgan E
• Moura-Letts, Gustavo

Titel

Synthesis of aminoalcohols from substituted alkenes via tungstenooxaziridine catalysis

Ist Teil von

• Organic & biomolecular chemistry, 2024-03, Vol.22 (11), p.2300-2306

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Herein we report the WO Dipic(H O) promoted oxyamination of alkenes using sulfonamides as the quantitative source of . The reaction works for activated and unactivated alkenes in high yields, diastereoselectivities, and stereospecificity. A catalytic cycle involving the formation of tungstenooxaziridine complex 1 as the active catalyst and hydrolysis of tungstenooxazolidine intermediate as the rate-determining-step has been proposed. Initial kinetic and competition experiments provide evidence for the proposed mechanism.