Details

Autor(en) / Beteiligte

• Matsuura, Hiroaki
• Makimoto, Go
• Oda, Naohiro
• Ninomiya, Kiichiro
• Higo, Hisao
• Fujii, Masanori
• Rai, Kammei
• Ichihara, Eiki
• Ohashi, Kadoaki
• Hotta, Katsuyuki
• Tabata, Masahiro
• Maeda, Yoshinobu

Titel

A Prompt Diagnosis and Treatment of a Case of Nuclear Protein of the Testis Carcinoma Characterized by a Bronchial Lesion and High Serum Alpha-fetoprotein Level Following Genomic Testing

Ist Teil von

• Internal Medicine, 2024, pp.2938-23

Ort / Verlag

Japan: The Japanese Society of Internal Medicine

Erscheinungsjahr

2024

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Nuclear protein of the testis carcinoma (NUTC) is a rare and aggressive malignancy. We herein report a case of NUTC in the lung characterized by a bronchial lesion and elevated alpha-fetoprotein levels. A 35-year-old Japanese man presented to our institution with suspected advanced lung cancer based on a histological examination. Subsequently, next-generation sequencing (NGS) yielded a positive BRD4-NUTM1 fusion. In addition, positive NUT immunostaining of the lung biopsy specimen confirmed NUTC in the lungs. Systemic chemotherapy and radiotherapy showed a temporary response, with decreased serum alpha-fetoprotein levels. We highlight this case of a prompt diagnosis by NGS of NUTC in a young individual with a rapidly progressing tumor.