Details

Autor(en) / Beteiligte

• Febrero, Beatriz
• Ruiz‐Manzanera, Juan José
• Ros‐Madrid, Inmaculada
• Hernández, Antonio Miguel
• Orenes‐Piñero, Esteban
• Rodríguez, José Manuel

Titel

Tumor microenvironment in thyroid cancer: Immune cells, patterns, and novel treatments

Ist Teil von

• Head & neck, 2024-06, Vol.46 (6), p.1486-1499

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2024

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• The tumor immune microenvironment of thyroid cancer is the heterogeneous histological space in which tumor cells coexist with host cells. Published data from this review were identified by search and selection database of Pubmed, Elsevier, and Science Direct. Searching was made in two steps using different keywords. In thyroid pathology, the inflammatory response is very important, and might have a key role finding new diagnostic and therapeutic methods, particularly in thyroid cancer. Different immune cells may be more or less present in different types of thyroid cancer and may even have different functions, hence the importance of knowing their presence in different thyroid tumor pathologies. Cancer‐related inflammation could be a useful target for new diagnostic and therapeutic strategies by analyzing peritumoral and intratumoral immune cells in different types of thyroid tumors. Moreover, novel strategies for thyroid cancer treatments, such as monoclonal antibodies targeting checkpoint inhibitors, are emerging as promising alternatives.