Details

Autor(en) / Beteiligte

• Payton, Kurlen S E
• Bennett, Mihoko V
• Schulman, Joseph
• Benitz, William E
• Stellwagen, Lisa
• Darmstadt, Gary L
• Quinn, Jenny
• Kristensen-Cabrera, Alexandria I
• Breault, Courtney C
• Bolaris, Michael
• Lefrak, Linda
• Merrill, Jeff
• Sharek, Paul J

Titel

28 NICUs participating in a quality improvement collaborative targeting early-onset sepsis antibiotic use

Ist Teil von

• Journal of perinatology, 2024-07, Vol.44 (7), p.1061-1068

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• There is widespread overuse of antibiotics in neonatal intensive care units (NICUs). The objective of this study was to safely reduce antibiotic use in participating NICUs by targeting early-onset sepsis (EOS) management. Twenty-eight NICUs participated in this statewide multicenter antibiotic stewardship quality improvement collaborative. The primary aim was to reduce the total monthly mean antibiotic utilization rate (AUR) by 25% in participant NICUs. Aggregate AUR was reduced by 15.3% (p < 0.001). There was a wide range in improvement among participant NICUs. There were no increases in EOS rates or nosocomial infection rates related to the intervention. Participation in this multicenter NICU antibiotic stewardship collaborative targeting EOS was associated with an aggregate reduction in antibiotic use. This study informs efforts aimed at sustaining improvements in NICU AURs.