Details

Autor(en) / Beteiligte

• García-Rodríguez, Gabriel
• Duque-Molina, Célida
• Kondo-Padilla, Irasema
• Zaragoza-Jiménez, Christian Arturo
• González-Cortés, Vladimir Brian
• Flores-Antonio, Rocio
• Villa-Reyes, Tania
• Vargas-Rubalcava, Adriana
• Ruano-Calderon, Luis Ángel
• Tinoco-Favila, Juan Carlos
• Sánchez-Salazar, Héctor Carlos
• Rivas-Ruiz, Rodolfo
• Castro-Escamilla, Octavio
• Martínez-Gamboa, Rosa Areli
• González-Lara, Fernanda
• López-Martínez, Irma
• Chiller, Tom M
• Pelayo, Rosana
• Bonifaz, Laura C
• Robledo-Aburto, Zoe
• Alcocer-Varela, Jorge

Titel

Outbreak of Fusarium solani Meningitis in Immunocompetent Persons Associated With Neuraxial Blockade in Durango, Mexico, 2022-2023

Ist Teil von

• Open forum infectious diseases, 2024-02, Vol.11 (2), p.ofad690-ofad690

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2024

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Fungal meningitis can be associated with epidural anesthesia procedures. Fusariosis is a rare infection typically affecting immunocompromised patients and rarely causes meningitis. During 2022-2023, public health officials responded to a large outbreak of meningitis associated with epidural anesthesia in Durango, Mexico. The public health response and epidemiological and clinical features of patients affected by this outbreak were described. Coordinated actions were addressed to identify the etiological agent, determine its drug susceptibility, develop diagnostic tests, and implement clinical and epidemiological protocols. Retrospective analyses of clinical variables and outcomes were performed to determine association with better patient survival. A total of 1801 persons exposed to epidural anesthesia were identified, of whom 80 developed meningitis. was found in 3 brain biopsies and showed susceptibility to voriconazole and amphotericin B. After polymerase chain reaction (PCR) implementation, 57 patients with meningitis were PCR-screened, and 31 (38.8%) had a positive result. Most patients were female (95%), and cesarean section was the most common surgical procedure (76.3%). The case fatality rate was 51.3% (41 patients) and the median hospitalization duration was 39.5 days (interquartile range, 18-86 days). Seventy-one patients (88.8%) received voriconazole/amphotericin B and 64 subjects (80%) additionally received steroids. Cox regression analysis showed an increased lethality risk in patients who received antifungal treatment after 5 days (hazard ratio, 2.1 [95% confidence interval, 1.01-4.48], < .05). The meningitis outbreak in Durango was an unprecedented medical challenge. Timely treatment and effective healthcare management were associated with better survival outcomes.