Details

Autor(en) / Beteiligte

• Xiao Liang, Kristina

Titel

Interplay of mitochondria and diabetes: Unveiling novel therapeutic strategies

Ist Teil von

• Mitochondrion, 2024-03, Vol.75, p.101850-101850, Article 101850

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• •Exploration of Mitochondrial Dysfunction in Diabetes: The review provides a comprehensive analysis of how mitochondrial dysfunction is intimately linked to diabetes, focusing on insulin resistance, beta-cell failure, and the role of genetic and epigenetic factors.•Incorporation of Latest Research and Novel Therapies: The paper includes the most recent advancements in mitochondrial research and diabetes, particularly highlighting innovative therapeutic strategies aimed at enhancing mitochondrial function to combat diabetes.•Impact of Mitochondrial Dynamics on Diabetes Progression: It delves into the significance of mitochondrial dynamics, including fusion, fission, and mitophagy, in the development and management of diabetes, emphasizing their role in cellular health and metabolic diseases.•Potential of Mitochondrial Biomarkers in Diabetes Management: The review explores the emerging field of mitochondrial biomarkers, discussing their potential in early diagnosis, prognosis, and monitoring of diabetes, thereby opening new avenues for targeted treatment approaches. The interplay between mitochondrial function and diabetes has gained significant attention due to its crucial role in the pathogenesis and progression of the disease. Mitochondria, known as the cellular powerhouses, are essential for glucose metabolism. Dysfunction of these organelles has been implicated in the development of insulin resistance and beta-cell failure, both prominent features of diabetes. This comprehensive review explores the intricate mechanisms involved, including the generation of reactive oxygen species and the impact of mitochondrial DNA (mtDNA) mutations. Moreover, the review delves into emerging therapeutic strategies that specifically target mitochondria, such as mitochondria-targeted antioxidants, agents promoting mitochondrial biogenesis, and compounds modulating mitochondrial dynamics. The potential of these novel approaches is critically evaluated, taking into account their benefits and limitations, to provide a well-rounded perspective. Ultimately, this review emphasizes the importance of advancing our understanding of mitochondrial biology to revolutionize the treatment of diabetes.