Details

Autor(en) / Beteiligte

• Kurniawan, Rahmat
• Sukrasno, Sukrasno
• Ashari, Arif
• Suhartati, Tati

Titel

Diving into paclitaxel: isolation and screening content from Taxus sumatrana at Singgalang Conservation Center, West Sumatra

Ist Teil von

• Natural product research, 2024-02, p.1-5

Ort / Verlag

England

Erscheinungsjahr

2024

Quelle

Taylor & Francis

Beschreibungen/Notizen

• The report features the first isolation of paclitaxel from wood of conservated . The is a nationally protected endemic plant that has been successfully cultivated outside its natural habitat at the Singgalang Conservation Centre in West Sumatra. The paclitaxel was utilised as a reference standard for evaluating its presence in different parts of . This analysis exhibits that the acetone extract from bark contained the highest paclitaxel concentration, measuring about 0.473 ± 0.031 ppm. The isolated paclitaxel demonstrated potent cytotoxic activity against A549, HeLa, and MCF7 cancer cells, by IC values of 3.26 ± 0.334, 2.85 ± 0.257, and 3.81 ± 0.013 μM, respectively. This outcome provides scientific support for conservation programs and campaigns for the community to engage in conservation efforts.