Details

Autor(en) / Beteiligte

• Allegra, Eugenia
• Bianco, Maria Rita
• Modica, Domenico Michele
• Azzolina, Alfio
• Privitera, Elio
• Latella, Daniele
• Occhiuzzi, Federico
• Galfano, Mario
• Saita, Vincenzo

Titel

Multicentric Study on Oncological Outcomes and Prognostic Factors of Open Partial Horizontal Laryngectomies

Ist Teil von

• Ear, nose, & throat journal, 2024-02, p.1455613231225906-1455613231225906

Ort / Verlag

United States

Erscheinungsjahr

2024

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• In recent years, the number of open preservation surgeries for the treatment of laryngeal Cancer has increased. This surgery aims to maintain laryngeal function and ensure oncological radicality, thereby avoiding a total laryngectomy (TL) that could significantly impact the patient's quality of life. The purpose of this study was to assess the oncologic results of OPHL I and II and to identify prognostic factors that could impact patient survival and local failure rates. This study was conducted on 182 patients with laryngeal squamous cell carcinoma treated with OPHLs between 2005 and 2015. The survival rates of a group of patients treated with TL between 2004 and 2014 were taken into consideration to compare survival outcomes. The disease-specific survival in pT2 and pT3 tumors in relation to the type of surgery showed no statistically significant difference between OPHLs and TL (  = .54 and  = .63, respectively). The 5-year T-recurrence-free survival showed that pT4 tumors, perineural/vascular positive invasion, and OPHL IIb + ARY-treated tumors were associated with a higher risk of tumor recurrence (  < .0001,  = .0005 and  = .016 respectively). OPHLs represent an excellent alternative to TL considering the characteristics of the tumor and the general conditions of the patient.