Details

Autor(en) / Beteiligte

• Yang, Jing
• Yan, Yuxin
• Yin, Xiya
• Liu, Xiangqi
• Reshetov, Igor V.
• Karalkin, Pavel A.
• Li, Qingfeng
• Huang, Ru-Lin

Titel

Bioengineering and vascularization strategies for islet organoids: advancing toward diabetes therapy

Ist Teil von

• Metabolism, clinical and experimental, 2024-03, Vol.152, p.155786-155786, Article 155786

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Diabetes presents a pressing healthcare crisis, necessitating innovative solutions. Organoid technologies have rapidly advanced, leading to the emergence of bioengineering islet organoids as an unlimited source of insulin-producing cells for treating insulin-dependent diabetes. This advancement surpasses the need for cadaveric islet transplantation. However, clinical translation of this approach faces two major limitations: immature endocrine function and the absence of a perfusable vasculature compared to primary human islets. In this review, we summarize the latest developments in bioengineering functional islet organoids in vitro and promoting vascularization of organoid grafts before and after transplantation. We highlight the crucial roles of the vasculature in ensuring long-term survival, maturation, and functionality of islet organoids. Additionally, we discuss key considerations that must be addressed before clinical translation of islet organoid-based therapy, including functional immaturity, undesired heterogeneity, and potential tumorigenic risks. [Display omitted] •Insulin dependent diabetic patients require islet transplantation to restore glucose homeostasis.•Islet organoids are emerging as an unlimited source of surrogate islets for treating diabetes.•Vascularization influences the engraftment, maturation, and functionality islet organoids•Islet organoids can be generated from hPSCs, pancreatic-derived cells, and nonpancreatic ASCs.•In vitro incorporating angiogenic cells enables fast vascularization of islet organoids after transplantation.