Details

Autor(en) / Beteiligte

• Chen, Rongsha
• Li, Ke
• Wang, Yinying
• Song, Liyun
• Wang, Ruohua
• Fan, Wenhui
• Zhao, Ninghui
• Zou, Wei
• Yang, Zhongshan
• Yan, Jinyuan

Titel

Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson's disease mouse model

Ist Teil von

• Journal of drug targeting, 2024-04, Vol.32 (4), p.423-432

Ort / Verlag

England

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Parkinson's disease (PD) is a central nervous system disease with the highest disability and mortality rate worldwide, and it is caused by a variety of factors. The most common medications for PD have side effects with limited therapeutic outcomes. Many studies have reported that chitosan oligosaccharide (COS) crossed blood-brain barrier to achieve a neuroprotective effect in PD. However, the role of COS in PD remains unclear. The present study demonstrated that COS increased dopaminergic neurons in the substantia nigra (SN) and ameliorated dyskinesia in a PD mouse model. Moreover, COS reduced gut microbial diversity and faecal short-chain fatty acids. Valeric acid supplementation enhanced the inflammatory response in the colon and SN, and it reversed COS - suppressed dopamine neurons damage. Autophagy was involved in COS modulating inflammation through valeric acid. These results suggest that COS reduces bacterial metabolites - valeric acid, which diminishes inflammation activating autophagy, ultimately alleviating PD.