Details

Autor(en) / Beteiligte

• Zhu, Qin‐qin
• Tian, Shui
• Zhang, Ling
• Ding, Hong‐yuan
• Gao, Ya‐xin
• Tang, Yin
• Yang, Xi
• Zhu, Yi
• Qi, Ming

Titel

Altered dynamic amplitude of low‐frequency fluctuation in individuals at high risk for Alzheimer's disease

Ist Teil von

• The European journal of neuroscience, 2024-05, Vol.59 (9), p.2391-2402

Ort / Verlag

France: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• The brain's dynamic spontaneous neural activity is significant in supporting cognition; however, how brain dynamics go awry in subjective cognitive decline (SCD) and mild cognitive impairment (MCI) remains unclear. Thus, the current study aimed to investigate the dynamic amplitude of low‐frequency fluctuation (dALFF) alterations in patients at high risk for Alzheimer's disease and to explore its correlation with clinical cognitive assessment scales, to identify an early imaging sign for these special populations. A total of 152 participants, including 72 SCD patients, 44 MCI patients and 36 healthy controls (HCs), underwent a resting‐state functional magnetic resonance imaging and were assessed with various neuropsychological tests. The dALFF was measured using sliding‐window analysis. We employed canonical correlation analysis (CCA) to examine the bi‐multivariate correlations between neuropsychological scales and altered dALFF among multiple regions in SCD and MCI patients. Compared to those in the HC group, both the MCI and SCD groups showed higher dALFF values in the right opercular inferior frontal gyrus (voxel P < .001, cluster P < .05, correction). Moreover, the CCA models revealed that behavioural tests relevant to inattention correlated with the dALFF of the right middle frontal gyrus and right opercular inferior frontal gyrus, which are involved in frontoparietal networks (R = .43, P = .024). In conclusion, the brain dynamics of neural activity in frontal areas provide insights into the shared neural basis underlying SCD and MCI. SCD and MCI patients performed significantly poorer than normal people on the neuropsychological scales. The neural activity of specific brain functional areas changed in the early stage of cognitive impairment. We observed a significant positive correlation between the aberrant dALFF values and clinical measurements of the three groups (R = .43, P = .024).