Details

Autor(en) / Beteiligte

• Zhang, Qian
• Pan, Hong
• Bian, Xue-Yan
• Yu, Jin-Han
• Wu, Long-Long
• Chen, Yi-Dan
• Li, Li
• Ji, Ling-Xi
• Yu, Ya-Li
• Han, Fei
• Huang, Jian
• Wang, Yong-Fei
• Yang, Yi

Titel

Crescent calculator: A webtool enabling objective decision-making for assessment of IgA nephropathy immune activity throughout the disease course

Ist Teil von

• Clinica chimica acta, 2024-03, Vol.555, p.117783-117783, Article 117783

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• •The Crescent Calculator was constructed to predict the likelihood of crescent lesions in individuals with IgAN by incorporating a range of clinical variables. This tool showed a good performance in two independent datasets. In addition, to fulfill varied clinical needs, multiple classification modes were established.•IgAN is an autoimmune disease. From the perspective of pathogenesis, the immune activity of IgAN is required a long-term dynamic monitoring. The Crescent Calculator could help clinicians monitoring the immune activity of patients with IgAN, empowering them to make timely, objective, and well-informed decisions concerning the necessity of kidney biopsies and more appropriate utilization of immunosuppressive therapy. IgA nephropathy (IgAN) is an immune-mediated glomerulonephritis, posing a challenge for the long-term management. It is crucial to monitor the disease’s activity over the disease course. Crescent lesions have been known as an active lesion associated with immune activity. We aimed to develop the Crescent Calculator to aid clinicians in making timely and well-informed decisions throughout the long-term disease course, such as renal biopsies and immunosuppressive therapy. 1,761 patients with biopsy-proven IgAN were recruited from four medical centers in Zhejiang Province, China. 16.9% presented crescent lesions. UPCR, URBC, eGFR and C4 were independently associated with the crescent lesions. By incorporating these variables, the Crescent Calculator was constructed to estimate the likelihood of crescent lesions. The predictor achieved AUC values of over 0.82 in two independent testing datasets. In addition, to fulfill varied clinical needs, multiple classification modes were established. The Crescent Calculator was developed to estimate the risk of crescent lesions for patients with IgAN, assisting clinicians in making timely, objective, and well-informed decisions regarding the need for renal biopsies and more appropriate use of immunosuppressive therapy in patients with IgAN.