Details

Autor(en) / Beteiligte

• Souza, Milena Silva
• Farias, Jéssica Pires
• Andreata‐Santos, Robert
• Silva, Marianne Pereira
• Brito, Ruth Dálety da Silva
• Duarte Barbosa da Silva, Marcia
• Peter, Cristina Mendes
• Cirilo, Marcus Vinícius de França
• Luiz, Wilson Barros
• Birbrair, Alexander
• Vidal, Paloma Oliveira
• Castro‐Amarante, Maria Fernanda
• Candido, Erika Donizetti
• Munhoz, Aldilene Silva
• Mello Malta, Fernanda
• Dorlass, Erik Gustavo
• Machado, Rafael Rahal Guaragna
• Pinho, João Renato Rebello
• Oliveira, Danielle Bruna Leal
• Durigon, Edison Luiz
• Maricato, Juliana Terzi
• Braconi, Carla Torres
• Ferreira, Luís Carlos de Souza
• Janini, Luiz Mário Ramos
• Amorim, Jaime Henrique

Titel

Neutralizing antibody response after immunization with a COVID‐19 bivalent vaccine: Insights to the future

Ist Teil von

• Journal of medical virology, 2024-02, Vol.96 (2), p.e29416-n/a

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• The raising of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants led to the use of COVID‐19 bivalent vaccines, which include antigens of the wild‐type (WT) virus, and of the Omicron strain. In this study, we aimed to evaluate the impact of bivalent vaccination on the neutralizing antibody (NAb) response. We enrolled 93 volunteers who had received three or four doses of monovalent vaccines based on the original virus (n = 61), or a booster shot with the bivalent vaccine (n = 32). Serum samples collected from volunteers were subjected to neutralization assays using the WT SARS‐CoV‐2, and Omicron subvariants. In addition, immunoinformatics to quantify and localize highly conserved NAb epitopes were performed. As main result, we observed that the neutralization titers of samples from individuals vaccinated with the bivalent vaccine were higher for the original virus, in comparison to their capacity of neutralizing the Omicron variant and its subvariants. NAb that recognize epitopes mostly conserved in the WT SARS‐CoV‐2 were boosted, while those that recognize epitopes mostly present in the Omicron variant, and subvariants were primed. These results indicate that formulation of future vaccines shall consider to target present viruses, and not viruses that no longer circulate.