Details

Autor(en) / Beteiligte

• Yen, Duong Thi Hai
• Hang, Dan Thi Thuy
• Yen, Pham Hai
• Tai, Bui Huu
• Dung, Duong Thi
• Huong, Phan Thi Thanh
• Dung, Nguyen Viet
• Trang, Do Thi
• Bang, Ngo Anh
• Mai, Nguyen Thi
• Kiem, Phan Van

Titel

Four Undescribed compounds Isolated from the Aerial Parts of Phyllanthus cochinchinensis with Antimicrobial Activity and NO Production Inhibitory Activity in LPS Activated RAW 264.7 Cells

Ist Teil von

• Chemistry & biodiversity, 2024-03, Vol.21 (3), p.e202302105-n/a

Ort / Verlag

Switzerland: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

Wiley-Blackwell subscription journals

Beschreibungen/Notizen

• Four previously undescribed compounds named phyllancosides A and B (1 and 2), and phyllancochines A and B (3 and 4) together with ten known compounds (5‐14) were isolated from the aerial parts of Phyllanthus cochinchinensis Spreng. Their chemical structures were elucidated on the basis of comprehensive analysis of IR, HR‐ESI‐MS, 1D and 2D NMR spectra. The absolute configurations of 1 and 2 were determined by electronic circular dichroism (ECD) spectra. Compounds 3, 4, and 10 showed antimicrobial activity against E. faecalis, S. aureus, and B. cereus with the MIC values in range of 32–256 μg/mL. Compound 11 inhibited E. faecalis and B. cereus, and 7 inhibited S. aureus with the MIC values in range of 64–128 μg/mL. In addition, compounds 1, 3, 4, 8, and 9 showed significantly NO production inhibitory activity in LPS activated RAW 264.7 cells with IC50 values ranging from 36.57 to 56.34 μM.