Details

Autor(en) / Beteiligte

• Jin, Mengdie
• Zhai, Xinyun
• Huang, Yongkang
• Zhang, Mengzhen
• Ma, Tengfei
• Zeng, Zhichao
• Fu, Hao
• Yin, Leilei
• Zhang, Yabin
• Du, Yaping

Titel

Biocompatible Silica‐Coated Europium‐Doped CsPbBr3 Nanoparticles with Luminescence in Water for Zebrafish Bioimaging

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2024-06, Vol.20 (26), p.e2310238-n/a

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Cesium lead halide (CsPbX3, X = Br, Cl, and I) nanocrystals (NCs) are widely concerned and applied in many fields due to the excellent photoelectric performance. However, the toxicity of Pb and the loss of luminescence in water limit its application in vivo. A stable perovskite nanomaterial with good bioimaging properties is developed by incorporating europium (Eu) in CsPbX3 NCs followed with the surface coating of silica (SiO2) shell (CsPbX3:Eu@SiO2). Through the surface coating of SiO2, the luminescence stability of CsPbBr3 in water is improved and the leakage of Pb2+ is significantly reduced. In particular, Eu doping inhibits the photoluminescence quantum yield reduction of CsPbBr3 caused by SiO2 coating, and further reduces the release of Pb2+. CsPbBr3:Eu@SiO2 nanoparticles (NPs) show efficient luminescence in water and good biocompatibility to achieve cell imaging. More importantly, CsPb(ClBr)3:Eu@SiO2 NPs are obtained by adjusting the halogen components, and green light and blue light are realized in zebrafish imaging, showing good imaging effect and biosafety. The work provides a strategy for advanced perovskite nanomaterials toward biological practical application. A stable perovskite nanomaterial with good bioimaging activity is developed by incorporating europium (Eu) in CsPbX3 NCs followed by the surface coating of silica (SiO2) shell (CsPbX3:Eu@SiO2). The obtained nanoparticles show efficient luminescence in water and good biocompatibility to achieve cell and zebrafish imaging.