Details

Autor(en) / Beteiligte

• Hoang, Le-Thuy-Thuy-Trang
• Phan, Hoang-Vinh-Truong
• Nguyen-Si, Hoai-Vu
• Tran, Thanh-Nha
• Vo, Thi-Phi-Giao
• Le, Huong Thi Thu
• Dao, Ngoc-Van-Trang
• Huynh, Thi-Minh-Suong
• Mai, Dinh-Tri
• Dong, Phan-Si-Nguyen
• Nguyen, Van-Kieu

Titel

Tinctoric acid A-B, two new hopan-type triterpenoids from the Vietnamese lichen, Parmotrema tinctorum (Despr. ex Nyl.) hale with α-glucosidase inhibitory activity

Ist Teil von

• Natural product research, 2024-01, p.1-8

Ort / Verlag

England

Erscheinungsjahr

2024

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Two new hopan-type triterpenoids, namely tinctoric acid A-B ( ), were isolated from the lichen (Despr. ex Nyl.) Hale. Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR). The absolute configuration at C-22 of was established through DP4 probability. Compounds were evaluated for their inhibitory activity against glucosidase and found to be more potent than those of positive control (acarbose, IC 168 µM) with values IC 74.7 and 98.2 µM, respectively. Both of these compounds interacted well with enzyme α-glucosidase MAL32 through H-bonds and hydrophobic interaction.