Details

Autor(en) / Beteiligte

• Falahatdoost, Samira
• Prawer, Yair D. J.
• Peng, Danli
• Chambers, Andre
• Zhan, Hualin
• Pope, Leon
• Stacey, Alastair
• Ahnood, Arman
• Al Hashem, Hassan N.
• De León, Sorel E.
• Garrett, David J.
• Fox, Kate
• Clark, Michael B.
• Ibbotson, Michael R.
• Prawer, Steven
• Tong, Wei

Titel

Control of Neuronal Survival and Development Using Conductive Diamond

Ist Teil von

• ACS applied materials & interfaces, 2024-01, Vol.16 (4), p.4361-4374

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular–substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering.