Details

Autor(en) / Beteiligte

• Li, Yunbing
• Li, Yuanyuan
• Li, Chunli
• Wang, Jingyu
• Tang, Jiayi
• Li, Ruichao
• Zhang, Guangfen
• Huang, Lili
• Zhou, Mi
• Xu, Chen
• Dong, Ning

Titel

Emergence of an ST1934:KL121 hypervirulent Klebsiella pneumoniae carrying a novel virulence-resistance hybrid plasmid with chromosomal integration of ICEKp1

Ist Teil von

• European journal of clinical microbiology & infectious diseases, 2024-03, Vol.43 (3), p.617-622

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• To identify the phenotypic and genomic characteristics of K. pneumoniae KP43 from bloodstream infection. KP43 was resistant to ticarcillin and tetracycline and was hypervirulent in the Galleria mellonella larvae infection model, positive for string test, and possessed high-level macrophage killing resistance. The hypervirulence phenotype was associated with the chromosome integration of ICE Kp1 carrying iroBCDN - iroP , rmpADC, and peg-344 , and a novel plasmid pKP43_vir_amr harboring iutAiucABCD . pKP43_vir_amr was an IncFIBκ/FII virulence-resistance hybrid conjugative plasmid which also carried antibiotic resistance genes. The emergence of such a strain and the spread of the novel virulence-resistance plasmid might pose a potential threat to public health.