Details

Autor(en) / Beteiligte

• Jin, Wenyu
• Liu, Huanbao
• Nie, Ping
• Li, Zihan
• Cheng, Xiang
• Jiao, Kunpeng
• Zhao, Guangxi
• Zheng, Guangming

Titel

Design and preparation of an artificial vascular scaffold with internal surface modification

Ist Teil von

• Artificial organs, 2024-05, Vol.48 (5), p.456-471

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Background Advances in regeneration methods have brought us improved vascular scaffolds with small diameters (φ < 6 mm) for enhancing biological suitability that solve their propensity for causing intimal hyperplasia post‐transplantation. Methods The correlation between the rehydration ratio of the hydrogel and its material concentration is obtained by adjusting the material ratio of the hydrogel solution. The vascular model with helical structure has been established and analyzed to verify the effect of helical microvascular structure on thrombosis formation by the fluid simulation methods. Then, the helical structure vascular has been fabricated by self‐developed 3D bioprinter, the vascular scaffolds are freeze‐dried and rehydrated in polyethylene glycol (PEG) solution. Results The experimental results showed that the hybrid hydrogel had a qualified rehydration ratio when the content of gelatin, sodium alginate, and glycerol was 5, 6, and 3 wt%. The established flow channel model can effectively reduce thrombus deposition and improve long‐term patency ratio. After PEG solution modification, the contact angle of the inner wall of the vascular scaffold was less than 30°, showing better hydrophilic characteristics. Conclusion In study, a small‐diameter inner wall vascular scaffold with better long‐term patency was successfully designed and prepared by wrinkling and PEG modification of the inner wall of the vascular scaffold. This study not only creates small‐diameter vascular scaffolds with helical structure that improves the surface hydrophilicity to reduce the risk of thrombosis but also rekindles confidence in the regeneration of small caliber vascular structures. The relationship between material concentration and rehydration ratio was established. The inner wall of the small‐diameter vascular scaffold was wrinkling modified, and the inner wall of the small‐diameter vascular scaffold was hydrophilic modified by PEG. It can reduce the risk of thrombosis and improve the long‐term patency of small‐diameter vascular scaffolds.