Details

Autor(en) / Beteiligte

• Ivanova, Mariia
• Belaya, Irina
• Kucháriková, Nina
• de Sousa Maciel, Izaque
• Saveleva, Liudmila
• Alatalo, Arto
• Juvonen, Ilona
• Thind, Navjot
• Andrès, Clarisse
• Lampinen, Riikka
• Chew, Sweelin
• Kanninen, Katja M.

Titel

Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model

Ist Teil von

• Neurobiology of disease, 2024-02, Vol.191, p.106410-106410, Article 106410

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Integrins are receptors that have been linked to various brain disorders, including Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin beta-3 (ITGB3) is known to participate in multiple cellular processes such as adhesion, migration, and signaling, its specific role in AD remains poorly understood, particularly in astrocytes, the main glial cell type in the brain. In this study, we investigated alterations in ITGB3 gene and protein expression during aging in different brain regions of the 5xFAD mouse model of AD and assessed the interplay between ITGB3 and astrocytes. Primary cultures from adult mouse brains were used to gain further insight into the connection between ITGB3 and amyloid beta (Aβ) in astrocytes. In vivo studies showed a correlation between ITGB3 and the astrocytic marker GFAP in the 5xFAD brains, indicating its association with reactive astrocytes. In vitro studies revealed increased gene expression of ITGB3 upon Aβ treatment. Our findings underscore the potential significance of ITGB3 in astrocyte reactivity in the context of Alzheimer's disease. •ITGB3 levels are increased in hippocampal and cortical regions in the 5xFAD mouse model of AD.•ITGB3 is co-localized with GFAP positive astrocytes in 5xFAD mouse brains.•Aβ increases Itgb3 mRNA expression in primary adult astrocytes in vitro.