Details

Autor(en) / Beteiligte

• Strobel, Katie M.
• Wood, Thomas R.
• Valentine, Gregory C.
• German, Kendell R.
• Gogcu, Semsa
• Hendrixson, D. Taylor
• Kolnik, Sarah E.
• Law, Janessa B.
• Mayock, Dennis E.
• Comstock, Bryan A.
• Heagerty, Patrick J.
• Juul, Sandra E.

Titel

Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age

Ist Teil von

• Journal of perinatology, 2024-06, Vol.44 (6), p.811-818

Ort / Verlag

New York: Nature Publishing Group US

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Associations of 2-year neurodevelopmental and behavioral outcomes with growth trajectories of preterm infants are unknown. Methods This secondary analysis of a preterm cohort examined in-hospital and discharge to 2-year changes in anthropometric z-scores. Two-year follow-up included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist. Results Among 590 infants, adjusted in-hospital growth was not associated with any BSID-III subscale. Occipitofrontal circumference (OFC) growth failure (GF) in-hospital was associated with increased adjusted odds of attention problems (aOR 1.65 [1.03, 2.65]), aggressive behavior (aOR 2.34 [1.12, 4.89]), and attention-deficit-hyperactivity symptoms (aOR 1.86 [1.05, 3.30]). Infants with OFC GF at 2 years had lower adjusted BSID-III language scores (−4.0 [−8.0, −0.1]), increased odds of attention problems (aOR 2.29 [1.11, 4.74]), aggressive behavior (aOR 3.09 [1.00, 9.56]), and externalizing problems (aOR 3.01 [1.07, 8.45]) compared to normal OFC growth cohort. Conclusion Infants with OFC GF are at risk for neurodevelopmental and behavioral impairment. Clinical trial registration This study is a secondary analysis of pre-existing data from the PENUT Trial Registration: NCT01378273.