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Establishment and Evaluation of a Mice Model of High-Altitude Cerebral Edema
Ist Teil von
Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban, 2023-11, Vol.54 (6), p.1269-1275
Ort / Verlag
China
Erscheinungsjahr
2023
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
To establish an animal model of high-altitude cerebral edema (HACE), to explore the altitude and oxygen partial pressure conditions that can lead to obvious clinical manifestations of HACE, and to lay the foundation for further research of the pathogenic mechanisms and intervention strategies of HACE.
Male BALB/c mice of 8 weeks old were randomly assigned to Control and HACE groups. The Control group (
=10) was treated with normobaric and normoxic conditions, while the HACE groups were placed in hypobaric hypoxic (HH) chambers for the durations of 6 h, 12 h, 24 h, 48 h and 72 h, respectively, receiving treatments of simulated HH conditions at the altitudes of 4000 m (
=10 for each group receiving different durations of HH treatment), 5000 m (
=10 for each group receiving different durations of HH treatment), and 6000 m (
=10 for each group receiving different durations of HH treatment). HE staining was performed to observe the morphological changes of the brain tissue and the appropriate simulated altitude co