Details

Autor(en) / Beteiligte

• Monteiro, Melissa S
• Mesquita, Marina S
• Garcia, Leidiane M
• Dos Santos, Paulo R
• de Marangoni de Viveiros, Cássia C
• da Fonseca, Ronei D
• Xavier, Mary A
• de Mendonça, Gabriel Ws
• Rosa, Suélia Srf
• Silva, Saulo Lp
• Paterno, Leonardo G
• Morais, Paulo C
• Báo, Sônia N

Titel

Radiofrequency driving antitumor effect of graphene oxide-based nanocomposites: a Hill model analysis

Ist Teil von

• Nanomedicine (London, England), 2024-02, Vol.19 (5), p.397-412

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• This report proposes using the Hill model to assess the benchmark dose, the 50% lethal dose, the cooperativity and the dissociation constant while analyzing cell viability data using nanomaterials to evaluate the antitumor potential while combined with radiofrequency therapy. A nanocomposite was synthesized (graphene oxide–polyethyleneimine–gold) and the viability was evaluated using two tumor cell lines, namely LLC-WRC-256 and B16-F10. Our findings demonstrated that while the nanocomposite is biocompatible against the LLC-WRC-256 and B16-F10 cancer cell lines in the absence of radiofrequency, the application of radiofrequency enhances the cell toxicity by orders of magnitude. This result points to prospective studies with the tested cell lines using tumor animal models.