Details

Autor(en) / Beteiligte

• Stumpf, Julian
• Anders, Leona
• Siepmann, Torsten
• Schwöbel, Jörg
• Karger, Claudia
• Lindner, Tom
• Faulhaber-Walter, Robert
• Langer, Torsten
• Escher, Katja
• Anding-Rost, Kirsten
• Seidel, Harald
• Hüther, Jan
• Pistrosch, Frank
• Martin, Heike
• Schewe, Jens
• Stehr, Thomas
• Meistring, Frank
• Paliege, Alexander
• Schneider, Daniel
• Bast, Ingolf
• Steglich, Anne
• Gembardt, Florian
• Kessel, Friederike
• Kröger, Hannah
• Arndt, Patrick
• Sradnick, Jan
• Frank, Kerstin
• Skrzypczyk, Sarah
• Anft, Moritz
• Klimova, Anna
• Mauer, René
• Roeder, Ingo
• Tonn, Torsten
• Babel, Nina
• Hugo, Christian

Titel

9-Month observational Dia-Vacc study of vaccine type influence on SARS-CoV-2 immunity in dialysis and kidney transplant patients

Ist Teil von

• Vaccine, 2024-01, Vol.42 (2), p.120-128

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• SARS-CoV-2mRNA vaccination related seroconversion rates are reduced in dialysis and kidney transplant patients. We evaluated nine months follow up data in our observational Dia-Vacc study exploring specific cellular (interferon-γ release assay) or/and humoral immune responses after 2x SARS-CoV-2mRNA vaccination in 880 participants including healthy medical personnel (125-MP), dialysis patients (595-DP), kidney transplant recipients (111-KTR), and apheresis patients (49-AP) with positive seroconversion (de novo IgA or IgG antibody positivity by ELISA) after eight weeks. Nine months after first vaccination, receptor binding domain (RBD) antibodies were still positive in 90 % of MP, 86 % of AP, but only 55 %/48 % of DP/KTR, respectively. Seroconversion remained positive in 100 % of AP and 99·2 % of MP, but 86 %/81 % of DP/KTR, respectively. Compared to MP, DP but not KTR or AP were at risk for a strong RBD decline, while KTR kept lowest RBD values over time. By multivariate analysis, BNT162b2mRNA versus 1273-mRNA vaccine type was an independent risk factor for a strong decline of RBD antibodies. Within the DP group, only time on dialysis was another (inverse) risk factor for the DP group. Compared to humoral immunity, T-cell immunity decline was less prominent. While seroconverted KTR reach lowest RBD values over time, DP are at specific risk for a strong decline of RBD antibodies after successful SARS-CoV-2mRNA vaccination, which also depends on the vaccine type being used. Therefore, booster vaccinations for DP should be considered earlier compared to normal population.