Details

Autor(en) / Beteiligte

• Abouyannis, Michael
• Esmail, Hanif
• Hamaluba, Mainga
• Ngama, Mwanajuma
• Mwangudzah, Hope
• Mumba, Noni
• Yeri, Betty K
• Mwalukore, Salim
• Alphan, Hassan J
• Aggarwal, Dinesh
• Alcoba, Gabriel
• Cammack, Nick
• Chippaux, Jean-Philippe
• Coldiron, Matthew E
• Gutiérrez, José M
• Habib, Abdulrazaq G
• Harrison, Robert A
• Isbister, Geoffrey K
• Lavonas, Eric J
• Martins, Diogo
• Ribeiro, Isabela
• Watson, James A
• Williams, David J
• Casewell, Nicholas R
• Walker, Sarah A
• Lalloo, David G

Titel

A global core outcome measurement set for snakebite clinical trials

Ist Teil von

• Médecine tropicale et santé internationale, 2023-09, Vol.3 (3)

Ort / Verlag

France

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials. Outcome domains were shortlisted by use of a questionnaire and consensus was reached among stakeholders and the patient group through facilitated discussions and voting. Five universal core outcome measures should be included in all future snakebite clinical trials: mortality, WHO disability assessment scale, patient-specific functional scale, acute allergic reaction by Brown criteria, and serum sickness by formal criteria. Additional syndrome-specific core outcome measures should be used depending on the biting species. This core outcome measurement set provides global standardisation, supports the priorities of patients and clinicians, enables meta-analysis, and is appropriate for use in low-income and middle-income settings.