Details

Autor(en) / Beteiligte

• Meng, Yan Hong
• Chen, Yi Fan
• Zhou, Pei Ru

Titel

Clinical and immunological features of primary Sjögren's syndrome patients with positive anti-centromere protein B antibody

Ist Teil von

• Beijing da xue xue bao. Journal of Peking University. Yi xue ban, 2023-12, Vol.55 (6), p.1088-1096

Ort / Verlag

China

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• To investigate the clinical and immunological features of primary Sjögren's syndrome (pSS) patients with positive anti-centromere protein B (CENP-B) antibody. In this cross-sectional study, the general clinical data, radiographic examination and labial salivary gland biopsy data, and serum immunological and biochemical data of patients diagnosed with pSS from January 2016 to August 2022 were evaluated. The included patients were divided into the anti-CENP-B antibody positive and negative groups. Intergroup differences were analyzed with SPSS 23.0 software. Subgroup analysis was further performed by dividing the anti-CENP-B antibody positive group into the single anti-CENP-B antibody positive and with other auto-antibodies positive groups to determine the characters related to anti-CENP-B antibody. In this study, 288 patients with pSS were evaluated, including 75 patients with anti-CENP-B antibody positive and 213 with anti-CENP-B antibody negative. Univariate analysis showed that compared with the anti-CENP-B