Details

Autor(en) / Beteiligte

• Franssen, Ruud F.W.
• Berkel, Annefleur E.M.
• ten Cate, David W.G.
• van der Palen, Job
• van Meeteren, Nico L.U.
• Vogelaar, F. Jeroen
• Slooter, Gerrit
• Klaase, Joost M.
• Janssen-Heijnen, Maryska L.G.
• Bongers, Bart C.

Titel

A retrospective analysis of the association of effort-independent cardiopulmonary exercise test variables with postoperative complications in patients who underwent elective colorectal surgery

Ist Teil von

• Langenbeck's archives of surgery, 2023-12, Vol.409 (1), p.7-7, Article 7

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose This study aimed to investigate the association of effort-independent variables derived from the preoperative cardiopulmonary exercise test (CPET) with 30-day postoperative complications after elective colorectal surgery. Methods A multicenter ( n =4) retrospective explorative study was performed using data of patients who completed a preoperative CPET and underwent elective colorectal surgery. The preoperative slope of the relation between minute ventilation and carbon dioxide production (VE/VCO 2 -slope) and the oxygen uptake efficiency slope (OUES), as well as 30-day postoperative complications, were assessed. Multivariable logistic regression analyses and receiver operating characteristic (ROC) curves were used to investigate the prognostic value of the relationship between these preoperative CPET-derived effort-independent variables and postoperative complications. Results Data from 102 patients (60.1% males) with a median age of 72.0 (interquartile range 67.8–77.4) years were analyzed. Forty-four patients (43.1%) had one or more postoperative complications (of which 52.3% general and 77.3% surgical complications). Merely 10 (9.8%) patients had a general complication only. In multivariate analysis adjusted for surgical approach (open versus minimally invasive surgery), the VE/VCO 2 -slope (odds ratio (OR) 1.08, confidence interval (CI) 1.02–1.16) and OUES (OR 0.94, CI 0.89–1.00) were statistically significant associated with the occurrence of 30-day postoperative complications. Conclusion The effort-independent VE/VCO 2 -slope and OUES might be used to assist in future preoperative risk assessment and could especially be of added value in patients who are unable or unwilling to deliver a maximal cardiorespiratory effort. Future research should reveal the predictive value of these variables individually and/or in combination with other prognostic (CPET-derived) variables for postoperative complications. Trial registration number ClinicalTrials.gov NCT05331196