Details

Autor(en) / Beteiligte

• Jelinek, Matyas
• Lipkova, Jolana
• Duris, Kamil

Titel

Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review

Ist Teil von

• Experimental neurology, 2024-02, Vol.372, p.114628-114628, Article 114628

Ort / Verlag

United States

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve's immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment.