Details

Autor(en) / Beteiligte

• Sett, Arun
• Roehr, Charles C
• Manley, Brett J

Titel

Surfactant as a drug carrier

Ist Teil von

• Seminars in fetal & neonatal medicine, 2023-12, Vol.28 (6), p.101499-101499, Article 101499

Ort / Verlag

Netherlands

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Drug delivery using a surfactant vehicle has the potential to prevent systemic side effects by delivering therapeutic agents directly to the respiratory system. The inherent chemical properties of surfactant allows it to readily distribute throughout the respiratory system. Therapeutic agents delivered by surfactant can primarily confer additional benefits but have potential to improve surfactant function. It is critically important that additional agents do not interefere with the innate surface tension lowering function of surfactant. Systemic evaluation through benchtop, translational and human trials are required to translate this potential technique into clinical practice.