Details

Autor(en) / Beteiligte

• Castaño-Díez, Sandra
• Pomares, Helena
• Esteban, Daniel
• Guijarro, Francesca
• Jiménez-Vicente, Carlos
• Zugasti, Inés
• Álamo, José Ramón
• Mayayo, Víctor Torrecillas
• López-Guerra, Mònica
• de la Fuente, Cristina
• Charry, Paola
• Cortés-Bullich, Albert
• Bataller, Álex
• Maluquer, Clara
• Colomer, Dolors
• Rozman, María
• Arnan, Montserrat
• Xicoy, Blanca
• Esteve, Jordi
• Díaz-Beyá, Marina

Titel

Characteristics and long-term outcome in a large series of chronic myelomonocytic leukaemia patients including 104 formerly referred to as oligomonocytic

Ist Teil von

• British journal of haematology, 2024-03, Vol.204 (3), p.892-897

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Recently modified diagnostic criteria for chronic myelomonocytic leukaemia (CMML) have lowered the cut-off for absolute monocytosis. In the largest series to date, we have analysed 313 CMML patients, including 104 with oligomonocytic (OM)-CMML. Five-year survival was longer for OM-CMML than for other patients (p < 0.001). Multivariate analysis identified OM-CMML as a favourable prognostic factor (HR 0.58; p = 0.002). The 5-year cumulative incidence of progression to classical CMML was 47%. Older age and transfusion dependence were adverse prognostic factors for OM-CMML. Our results support the inclusion of OM-CMML in the CMML category as a subtype with superior outcomes.