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The effect of body mass index on maternal and perinatal outcomes in COVID‐19 infection during pregnancy and postpartum: Secondary analysis from the REBRACO cohort study
Ist Teil von
International journal of gynecology and obstetrics, 2024-03, Vol.164 (3), p.1019-1027
Ort / Verlag
United States
Erscheinungsjahr
2024
Quelle
Wiley Online Library
Beschreibungen/Notizen
Objectives
To compare maternal and perinatal outcomes among women with obesity, overweight, and normal body mass index, associated with COVID‐19 infection during pregnancy and postpartum.
Method
Prospective Cohort Study, within the REBRACO (Brazilian Network of COVID‐19 in Pregnancy) multicenter initiative. Confirmed positive cases of SARS‐CoV‐2 were included, and women categorized into three groups according to their pre‐pregnancy BMI: obesity (BMI ≥ 30), overweight (BMI <30 but >25), and normal BMI. Sociodemographic, clinical, and obstetric characteristics and different maternal and perinatal outcomes were compared, and a multiple regression analysis was performed to investigate factors independently associated with adverse maternal and perinatal outcomes.
Results
Two hundred eighty‐nine women positive for SARS‐CoV‐2 infection were considered, and 202 had available data on maternal BMI for the current analysis. Overall, 72 (35.6%)obese, 68 (33.6%) overweight, and 60 (29.7%) normal BMI. Obesity was associated with increased adverse clinical outcomes including sepsis (P = 0.02), acute respiratory distress syndrome (P = 0.002), and the need for mechanical ventilation (P = 0.044). Considering perinatal outcomes, a multiple regression model confirmed obesity as an independent factor associated with adverse results (adjusted odds ratio 3.73, 95% CI 1.54–9.08).
Conclusion
Obesity and overweight were associated with worse clinical outcomes, severe/critical COVID‐19, and adverse perinatal outcomes.