Details

Autor(en) / Beteiligte

• Maniakas, Anastasios
• Sullivan, Andrew
• Hu, Mimi I.
• Busaidy, Naifa L.
• Cabanillas, Maria E.
• Dadu, Ramona
• Waguespack, Steven G.
• Fisher, Sarah B.
• Graham, Paul H.
• Gross, Neil D.
• Grubbs, Elizabeth G.
• Perrier, Nancy D.
• Wang, Jennifer R.
• Gunn, Brandon
• Garden, Adam S.
• Megahed, Romy
• Navuluri, Sriram
• Li, Xu
• Williams, Michelle D.
• Zafereo, Mark

Titel

Decreasing utilization for postoperative radiation therapy in locoregionally advanced medullary thyroid cancer

Ist Teil von

• Head & neck, 2024-02, Vol.46 (2), p.328-335

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Background Use of postoperative radiation therapy (PORT) in locoregionally advanced medullary thyroid cancer (MTC) remains controversial. The objective was to evaluate the effect of PORT on locoregional control (LRC) and overall survival (OS). Methods Retrospective cohort study of 346 MTC patients separated into PORT and no‐PORT cohorts. Relative indications for PORT, as well as changes in patterns of treatment, were recorded. Results 49/346 (14%) received PORT. PORT was associated with worse OS; adjusted HR = 2.0 (95%CI 1.3–3.3). PORT was not associated with improved LRC, even when adjusting for advanced stage (Stage III p = 0.892; Stage IV p = 0.101). PORT and targeted therapy were not associated with improved OS compared to targeted therapy alone; adjusted HR = 1.2 (95%CI 0.3–4.1). Conclusions Use of PORT in MTC has decreased and its indications have become more selective, coinciding with the advent of effective targeted therapies. Overall, PORT was not associated with improved LRC or OS.