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Variant-Specific IgA Protects Against Omicron Infection
Ist Teil von
The Journal of infectious diseases, 2023-11
Erscheinungsjahr
2023
Quelle
Oxford Journals 2020 Medicine
Beschreibungen/Notizen
Abstract
Background
The emergence of rapidly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, coupled with waning vaccine-induced immunity, has contributed to the rise of vaccine breakthrough infections. It is crucial to understand how vaccine-induced protection is mediated.
Methods
We examined 2 prospective cohorts of mRNA vaccinated and boosted individuals during the Omicron wave of infection in Singapore.
Results
We found that individuals who remain uninfected over the follow-up period had a higher variant-specific IgA, but not IgG, antibody response at 1 month after booster vaccination, compared with individuals who became infected.
Conclusions
We conclude that IgA may have a potential contributory role in protection against Omicron infection.
Clinical Trials Registration . NCT05142319.
Sprache
Englisch
Identifikatoren
ISSN: 0022-1899
eISSN: 1537-6613
DOI: 10.1093/infdis/jiad525
Titel-ID: cdi_proquest_miscellaneous_2893840801
Format
–
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