Details

Autor(en) / Beteiligte

• Yuen, Courtney M
• Huang, Chuan-Chin
• Millones, Ana Karina
• Calderon, Roger I
• Manson, Abigail L
• Jimenez, Judith
• Contreras, Carmen
• Earl, Ashlee M
• Becerra, Mercedes C
• Lecca, Leonid
• Murray, Megan B

Titel

Utility of Mycobacterium tuberculosis Genome Sequencing Snapshots to Assess Transmission Dynamics Over Time

Ist Teil von

• The Journal of infectious diseases, 2024-05, Vol.229 (5), p.1493-1497

Ort / Verlag

United States

Erscheinungsjahr

2024

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• We explored the utility of brief Mycobacterium tuberculosis whole-genome sequencing (WGS) "snapshots" at a sentinel site within Lima, Peru, for evaluating local transmission dynamics over time. Within a 17-km2 area, 15 of 70 (21%) isolates with WGS collected during 2011-2012 and 22 of 81 (27%) collected during 2020-2021 were clustered (P = .414), and additional isolates clustered with those from outside the area. Isolates from the later period were disproportionately related to large historic clusters in Lima from the earlier period. WGS snapshots at a sentinel site may not be useful for monitoring transmission, but monitoring the persistence of large transmission clusters might be.