Details

Autor(en) / Beteiligte

• Nguyen, Thanh Tat
• Nguyen, Dat Tat
• Vo, Tien Thi-Hong
• Dang, Oanh Tran-Hoang
• Nguyen, Bao Trung
• Pham, Dung Thi-Thuy
• Nguyen, Thuong Thi-Kim
• Duong, Yen Nguyen-Hoang
• Doan, Duong Hung
• Nguyen, Truc Huynh
• Ho, Lien Thi
• Nguyen, Phuc Hoang
• Phan, Dung Ngoc
• Tran, Tin Van
• Nguyen, Tuyet Kim
• Luong, Duc Cong
• Pham, Anh Thi-Mai
• Dinh, Thuy Thi-Diem
• Do, Viet Chau
• Vo, Luan Thanh

Titel

Associations of obesity and dengue-associated mortality, acute liver failure and mechanical ventilation in children with dengue shock syndrome

Ist Teil von

• Medicine (Baltimore), 2023-11, Vol.102 (46), p.e36054-e36054

Erscheinungsjahr

2023

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Dengue-associated complications, including dengue shock syndrome, severe respiratory distress, and pediatric acute liver failure (PALF), are associated with high mortality rates in patients with dengue. There is increasing prevalence of overweight and obesity among children worldwide. Obesity may activate inflammatory mediators, leading to increased capillary permeability and plasma leakage in patients with dengue. Several studies have shown a correlation between obesity and DSS, but did not include dengue fatality or PALF. Therefore, we hypothesized possible associations between obesity and critical dengue-associated clinical outcomes among PICU-admitted children with DSS, including dengue-related mortality, mechanical ventilation (MV) requirements, and dengue-associated PALF. The nutritional status of the participants was assessed using World Health Organization growth charts. A total of 858 participants with complete nutritional data were enrolled in this study. Obesity was significantly associated with risk of severe respiratory failure and MV support (odds ratio = 2.3, 95% CI: 1.31–4.06, P < .01); however, it was not associated with dengue-associated mortality or acute liver failure. Obese pediatric patients with DSS should be closely monitored for severe respiratory distress and the need for high-flow oxygenation support, particularly MV, soon after hospitalization.