Details

Autor(en) / Beteiligte

• Liang, Yi-En
• Chang, Ming-Yiang
• Ho, Hsi
• Chiou, Chun-Tang
• Barve, Balaji D.
• Li, Wen-Tai

Titel

Palladium-Catalyzed Cascade Endo - dig Cycloisomerization and Olefination with Alkenes to Access Fused Oxatricyclic Compounds

Ist Teil von

• Organic letters, 2023-11, Vol.25 (46), p.8194-8198

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A novel cascade Pd(II)-catalyzed endo-dig cycloisomerization and olefination reaction of 2-benzyl-3-alkynyl chromones with activated/unactivated alkenes has been developed for the synthesis of fused oxatricyclic compounds. This concise one-pot synthetic approach was applied to the difunctionalization of unbiased alkynes based on 2-benzyl-3-(alkynyl)-4H-chromen-4-one via O-attack endo-dig cycloisomerization, followed by olefination with both activated and unactivated alkenes.