Details

Autor(en) / Beteiligte

• Windpessl, Martin
• Odler, Balazs
• Bajema, Ingeborg M.
• Geetha, Duvuru
• Säemann, Marcus
• Lee, Jiwon M.
• Vaglio, Augusto
• Kronbichler, Andreas

Titel

Glomerular Diseases Across Lifespan: Key Differences in Diagnostic and Therapeutic Approaches

Ist Teil von

• Seminars in nephrology, 2023-07, Vol.43 (4), p.151435-151435, Article 151435

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Glomerular diseases are common causes of chronic kidney disease in childhood, adolescence, and adulthood. The epidemiology of glomerular diseases differs between different age groups, with minimal change disease being the leading cause of nephrotic syndrome in childhood, while membranous nephropathy and focal segmental glomerulosclerosis are more common in adulthood. IgA vasculitis is also more common in childhood. Moreover, there is a difference in disease severity with more children presenting with a relapsing form of nephrotic syndrome and a more acute presentation of antineutrophil cytoplasmic antibody–associated vasculitis and concomitant glomerulonephritis, as highlighted by the higher percentage of cellular crescents on kidney biopsy specimens in comparison with older patients. There is also a female preponderance in antineutrophil cytoplasmic antibody–associated vasculitis and more children present with tracheobroncholaryngeal disease. This article aims to summarize differences in the presentation of different glomerular diseases that are encountered commonly by pediatric and adult nephrologists and potential differences in the management.