Details

Autor(en) / Beteiligte

• Umeda, Kairi
• Iwasaki, Arihiro
• Taguchi, Raimu
• Kurisawa, Naoaki
• Jeelani, Ghulam
• Nozaki, Tomoyoshi
• Suenaga, Kiyotake

Titel

Isolation and Structure Determination of Akunolides, Macrolide Glycosides from a Marine Okeania sp. Cyanobacterium

Ist Teil von

• Journal of natural products (Washington, D.C.), 2023-11, Vol.86 (11), p.2529-2538

Ort / Verlag

United States

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Akunolides A ( ), B ( ), C ( ), and D ( ), new macrolide glycosides, were isolated from a marine sp. cyanobacterium. Their structures were elucidated by spectroscopic analyses and derivatization reactions. Akunolides A-D ( - ) are classified as 16-membered macrolide glycosides, which are relatively rare structures for marine cyanobacterium-derived natural products. Akunolides A-D ( - ) showed moderate antitrypanosomal activities against , with IC values ranging from 11 to 14 μM. Furthermore, akunolides A ( ) and C ( ) exhibited no cytotoxicity against normal human WI-38 cells even at a concentration of 150 μM.