Details

Autor(en) / Beteiligte

• Salas-Orozco, Marco Felipe
• Lorenzo-Leal, Ana Cecilia
• de Alba Montero, Idania
• Marín, Nuria Patiño
• Santana, Miguel Angel Casillas
• Bach, Horacio

Titel

Mechanism of escape from the antibacterial activity of metal-based nanoparticles in clinically relevant bacteria: A systematic review

Ist Teil von

• Nanomedicine, 2024-01, Vol.55, p.102715-102715, Article 102715

Ort / Verlag

United States

Erscheinungsjahr

2024

Quelle

ScienceDirect Pay Per View(PPV) Titles

Beschreibungen/Notizen

• The emergency of antibiotic-resistant bacteria in severe infections is increasing, especially in nosocomial environments. The ESKAPE group is of special importance in the groups of multi-resistant bacteria due to its high capacity to generate resistance to antibiotics and bactericides. Therefore, metal-based nanomaterials are an attractive alternative to combat them because they have been demonstrated to damage biomolecules in the bacterial cells. However, there is a concern about bacteria developing resistance to NPs and their harmful effects due to environmental accumulation. Therefore, this systematic review aims to report the clinically relevant bacteria that have developed resistance to the NPs. According to the results of this systematic review, various mechanisms to counteract the antimicrobial activity of various NP types have been proposed. These mechanisms can be grouped into the following categories: production of extracellular compounds, metal efflux pumps, ROS response, genetic changes, DNA repair, adaptative morphogenesis, and changes in the plasma membrane.