Details

Autor(en) / Beteiligte

• Pouvreau, Pierre
• Coelho, Julien
• Rumeau, Cécile
• Malard, Olivier
• Garrel, Renaud
• Michel, Justin
• Righini, Christian
• Vergez, Sebastien
• Baudouin, Robin
• Bastit, Vianney
• Marie, Jean-Paul
• Villepelet, Aude
• Moya-Plana, Antoine
• Philouze, Pierre
• Saroul, Nicolas
• Digue, Laurence
• Daste, Amaury
• Renard, Sophie
• Moriniere, Sylvain
• Carsuzaa, Florent
• Verillaud, Benjamin
• Poissonnet, Gilles
• Schultz, Philippe
• Brenet, Esteban
• Mouawad, François
• Thariat, Juliette
• Vulquin, Noémie
• Castain, Claire
• de Gabory, Ludovic
• Dupin, Charles

Titel

Management of 80 sinonasal undifferentiated carcinomas. Retrospective multicentre study of the French Network of Rare Head and Neck Cancers (REFCOR)

Ist Teil von

• European journal of surgical oncology, 2023-12, Vol.49 (12), p.107108-107108, Article 107108

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive disease requiring multimodal treatment, and multiple new entities once included in the spectrum of SNUC, such as SWI/SNF-deficient carcinomas, are emerging. We aimed to provide new data regarding the role of chemotherapy and surgery and the prognostic factors of disease-free survival. This study was based on data from the REFCOR database and included patients with SNUC treated with curative intent from 2007 to 2021 across 22 centres in France. A total of 80 patients were included in the analysis. Among the entire cohort, the 5-year disease-free survival (DFS) and overall survival (OS) rates were 58% and 63%, respectively. Of 100% of the patients treated with irradiation, 29% underwent surgery, 56% neoadjuvant chemotherapy (82% had either a partial or a complete response) and 76% chemoradiotherapy. No treatment modality was associated with a better OS or DFS, including surgery (p = 0.34). There was a trend for a better DFS for the patients treated with chemotherapy (neoadjuvant or concomitant, p = 0.062). Overall survival at 3 years was 58% for SWI/SNF deficient group and 86% for non deficient group (p = 0.14). The locoregional relapse rate without distant metastases was 21% in the exclusive radiotherapy group and 26% in the surgery group. Grade 3 or higher toxicities concerned 9%, 32% and 29% of patients for surgery, radiotherapy and chemotherapy respectively. In the management of localised SNUC among all patients treated with irradiation, surgery yielded no benefit, whereas the addition of chemotherapy tended to improve disease-free survival. [Display omitted] •Confirmed SNUC remain rare head and neck cancers•Surgery does not improve disease free survival nor overall survival compared to exclusive radiotherapy•Neoadjuvant and/or concomitant chemotherapy tends to improve disease-free survival•SWI/SNF-deficient carcinoma tumours tend to have worse prognosis than SWi/SNF non deficient tumours