Details

Autor(en) / Beteiligte

• Pince, Claire L.
• Whiting, Kimberly E.
• Wang, Tammy
• Lékó, András H.
• Farinelli, Lisa A.
• Cooper, Diane
• Farokhnia, Mehdi
• Vendruscolo, Leandro F.
• Leggio, Lorenzo

Titel

Role of aldosterone and mineralocorticoid receptor (MR) in addiction: A scoping review

Ist Teil von

• Neuroscience and biobehavioral reviews, 2023-11, Vol.154, p.105427-105427, Article 105427

Ort / Verlag

United States: Elsevier Ltd

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Preclinical and human studies suggest a role of aldosterone and mineralocorticoid receptor (MR) in addiction. This scoping review aimed to summarize (1) the relationship between alcohol and other substance use disorders (ASUDs) and dysfunctions of the aldosterone and MR, and (2) how pharmacological manipulations of MR may affect ASUD-related outcomes. Our search in four databases (MEDLINE, Embase, Web of Science, and Cochrane Library) indicated that most studies focused on the relationship between aldosterone, MR, and alcohol (n = 30), with the rest focused on opioids (n = 5), nicotine (n = 9), and other addictive substances (n = 9). Despite some inconsistencies, the overall results suggest peripheral and central dysregulations of aldosterone and MR in several species and that these dysregulations depended on the pattern of drug exposure and genetic factors. We conclude that MR antagonism may be a promising target in ASUD, yet future studies are warranted. •Mineralocorticoid receptor (MR) gene expression is altered in addiction.•MR ligands (aldosterone and cortisol) are altered in addiction.•The MR antagonist spironolactone reduces alcohol intake in rodents.•MR is a potential therapeutic target in alcohol use disorder.•MR – opioid/psychostimulant/nicotine relationships require future research.