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Experimental models of human cortical malformations: from mammals to 'acortical' zebrafish
Ist Teil von
Neuroscience and biobehavioral reviews, 2023-12, Vol.155, p.105429-105429, Article 105429
Ort / Verlag
United States: Elsevier Ltd
Erscheinungsjahr
2023
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Human neocortex controls and integrates cognition, emotions, perception and complex behaviors. Aberrant cortical development can be triggered by multiple genetic and environmental factors, causing cortical malformations. Animal models, especially rodents, are a valuable tool to probe molecular and physiological mechanisms of cortical malformations. Complementing rodent studies, the zebrafish (Danio rerio) is an important model organism in biomedicine. Although the zebrafish (like other fishes) lacks neocortex, here we argue that this species can still be used to model various aspects and brain phenomena related to human cortical malformations. We also discuss novel perspectives in this field, covering both advantages and limitations of using mammalian and zebrafish models in cortical malformation research. Summarizing mounting evidence, we also highlight the importance of translationally-relevant insights into the pathogenesis of cortical malformations from animal models, and discuss future strategies of research in the field.
•Cortical malformations are a diverse family of rare human brain disorders.•Mammalian models are widely used to probe pathobiology of cortical malformations.•Lacking neocortex, zebrafish are widely used to study brain disorders.•Mounting evidence suggests zebrafish as a novel model for cortical malformations research.•We discuss advantages and limitations of animal models of cortical malformations.