Details

Autor(en) / Beteiligte

• Stær, Kristian
• Iranzo, Alex
• Terkelsen, Miriam Højholt
• Stokholm, Morten Gersel
• Danielsen, Erik Hvid
• Østergaard, Karen
• Serradell, Mónica
• Otto, Marit
• Svendsen, Kristina B.
• Garrido, Alicia
• Vilas, Dolores
• Santamaria, Joan
• Møller, Arne
• Gaig, Carles
• Brooks, David J.
• Borghammer, Per
• Tolosa, Eduardo
• Pavese, Nicola

Titel

Progression of brain cholinergic dysfunction in patients with isolated rapid eye movement sleep behavior disorder

Ist Teil von

• European journal of neurology, 2024-01, Vol.31 (1), p.e16101-n/a

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Background Reduced cortical acetylcholinesterase activity, as measured by 11C‐donepezil positron emission tomography (PET), has been reported in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD). However, its progression and clinical implications have not been fully investigated. Here, we explored the relationship between longitudinal changes in brain acetylcholinesterase activity and cognitive function in iRBD. Methods Twelve iRBD patients underwent 11C‐donepezil PET at baseline and after 3 years. PET images were interrogated with statistical parametric mapping (SPM) and a regions of interest (ROI) approach. Clinical progression was assessed with the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale‐Part III (MDS‐UPDRS‐III). Cognitive function was rated using the Mini‐Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Results From baseline to follow‐up, the mean 11C‐donepezil distribution volume ratio (DVR) decreased in the cortex (p = 0.006), thalamus (p = 0.013), and caudate (p = 0.013) ROI. Despite no significant changes in the group mean MMSE or MoCA scores being observed, individually, seven patients showed a decline in their scores on these cognitive tests. Subgroup analysis showed that only the subgroup of patients with a decline in cognitive scores had a significant reduction in mean cortical 11C‐donepezil DVR. Conclusions Our results show that severity of brain cholinergic dysfunction in iRBD patients increases significantly over 3 years, and those changes are more severe in those with a decline in cognitive test scores.