Details

Autor(en) / Beteiligte

• Jan, Nusrat
• Sofi, Shazia
• Qayoom, Hina
• Haq, Burhan Ul
• Shabir, Aisha
• Mir, Manzoor Ahmad

Titel

Targeting breast cancer stem cells through retinoids: A new hope for treatment

Ist Teil von

• Critical reviews in oncology/hematology, 2023-12, Vol.192, p.104156-104156, Article 104156

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Breast cancer is a complex and diverse disease accounting for nearly 30% of all cancers diagnosed in females. But unfortunately, patients develop resistance to the existing chemotherapeutic regimen, resulting in approximately 90% treatment failure. With over half a million deaths annually, it is imperative to explore new therapeutic approaches to combat the disease. Within a breast tumor, a small sub-population of heterogeneous cells, with a unique ability of self-renew and differentiation and responsible for tumor formation, initiation, and recurrence are referred to as breast cancer stem cells (BCSCs). These BCSCs have been identified as one of the main contributors to chemoresistance in breast cancer, making them an attractive target for developing novel therapeutic strategies. These cells exhibit surface biomarkers such as CD44+, CD24-/LOW, ALDH, CD133, and CD49f phenotypes. Higher expression of CD44+ and ALDH activity has been associated with the formation of tumors in various cancers. Moreover, the abnormal regulation of signaling pathways, including Hedgehog, Notch, β-catenin, JAK/STAT, and P13K/AKT/mTOR, leads to the formation of cancer stem cells, resulting in the development of tumors. The growing drug resistance in BC is a significant challenge, highlighting the need for new therapeutic strategies to combat this dreadful disease. Retinoids, a large group of synthetic derivatives of vitamin A, have been studied as chemopreventive agents in clinical trials and have been shown to regulate various crucial biological functions including vision, development, inflammation, and metabolism. On a cellular level, the retinoid activity has been well characterized and translated and is known to induce differentiation and apoptosis, which play important roles in the outcome of the transformation of tissues into malignant. Retinoids have been investigated extensively for their use in the treatment and prevention of cancer due to their high receptor-binding affinity to directly modulate gene expression programs. Therefore, in this study, we aim to summarize the current understanding of BCSCs, their biomarkers, and the associated signaling pathways. Retinoids, such as Adapalene, a third-generation retinoid, have shown promising anti-cancer potential and may serve as therapeutic agents to target BCSCs. [Display omitted] •Breast cancer is the most deadly carcinoma among females worldwide and breast cancer stem cells characterize to be main cause.•Their ability to self-renewal, differentiation and resistance to current treatments are making them prognostic targets.•Retinoids are a class of vitamin A derivatives that has shown promise in targeting BCSCs by reducing their ability to support tumor growth.•Retinoids and their synthetic derivatives represent to be the promising therapeutics to target BCSCs through various pathways.•In our study, we have discussed in detail about the therapeutic potential of retinoids in inhibiting the potential targets in BCSCs.