Details

Autor(en) / Beteiligte

• Fernanda Arias-Santé, M.
• Fuentes, Jocelyn
• Ojeda, Camila
• Aranda, Mario
• Pastene, Edgar
• Speisky, Hernán

Titel

Amplification of the antioxidant properties of myricetin, fisetin, and morin following their oxidation

Ist Teil von

• Food chemistry, 2024-03, Vol.435, p.137487-137487, Article 137487

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2024

Quelle

ScienceDirect

Beschreibungen/Notizen

• •Oxidation of flavonols substantially amplifies their antioxidant properties.•Amplification arises from converting the pyrane ring into a hydroxyl-furanone ring.•2-benzoyl-2-hydroxy-3(2H)-benzofuranones emerge as a novel type of antioxidants. Quercetin oxidation leads to the formation of a metabolite, 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone, whose antioxidant potency was recently reported to be a 1000-fold higher than that of its precursor. The formation of similar metabolites (BZF) is limited to certain flavonols (FL), among which are myricetin, fisetin, and morin. Here we addressed the consequences of inducing the auto-oxidation of these flavonols in terms of their antioxidant properties (assessed in ROS-exposed Caco-2 cells). The mixtures that result from their oxidation (FLox) exhibited antioxidant activities 10-to-50-fold higher than those of their precursors. Such amplification was fully attributable to the presence of BZF in each FLox (established by HPLC-ESI-MS/MS and chemical subtraction techniques). An identical amplification was also found when the antioxidant activities of BZF, isolated from each FLox, and FL were compared. These findings warrant the search of these BZF in edible plants and their subsequent evaluation as a new type of functional food ingredients.