Details

Autor(en) / Beteiligte

• Batista, Kamila Sabino
• Lima, Marcos dos Santos
• Francisco Alves, Adriano
• Cavalcante, Hassler Clementino
• de Souza, Danielle Melo
• de Oliveira, Guilherme Costa
• Toscano, Lydiane Tavares
• Silva, Alexandre Sérgio
• Rodrigues, Josuel Feitosa
• de Albuquerque Meireles, Bruno Raniere Lins
• de Magalhães Cordeiro, Angela Maria Tribuzy
• Persuhn, Darlene Camati
• de Souza Aquino, Jailane

Titel

Antioxidant potential of acerola by-product along the enterohepatic axis of rats fed a high-fat diet

Ist Teil von

• Food research international, 2023-11, Vol.173, p.113380-113380, Article 113380

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •Acerola by-product (ABP) presented high antioxidant compound concentrations.•Phenolic compounds are the main antioxidant compounds of ABP.•ABP increased phenolic compounds in the enterohepatic axis of rats.•ABP reduced the degree of hepatic steatosis in the rats fed a high-fat diet.•ABP minimized oxidative damage in the enterohepatic axis of rats. Acerola (Malpighia emarginata DC) by-product (ABP) has bioactive compounds that can provide antioxidant and hypolipidemic effects in vivo. In this study we aimed to evaluate the antioxidant potential of ABP on oxidative damage along the enterohepatic axis of rats fed a high-fat diet for 7 weeks. In addition, we analysed the phenolic compound profile in the enterohepatic axis, and the lipid accumulation in the liver, colon and liver tissue structure of high-fat diet-fed rats treated with fenofibrate drug (100 mg/kg) or ABP (400 mg/kg) via orogastric administration in the 4th to 7th weeks of the experiment. ABP had increased antioxidant potential in vitro and presented ascorbic acid (2022.06 μg/g), carotenoid (2.63 μg/g), and total phenolic compound (5366.44 μg/g) contents. The high-fat diet-fed rats that received ABP (compared to fenofibrate treatment) presented a non-significant reduction of 9.87% in guanine oxidation product, lower relative liver weight, degree of hepatic steatosis, and aspartate aminotransferase level in their blood. ABP also provided high-fat diet-fed rats: an increased amount of total phenolic compounds in caecal digesta (946.42 µg/g), faeces (3299.07 µg/g), colon (256.15 µg/g) and hepatic tissues (454.80 µg/g); higher total antioxidant capacity in plasma and colon; and lower lipid peroxidation in plasma, colonic and hepatic tissues. The results point to the potential antioxidant activity of ABP against oxidative damage along the enterohepatic axis caused by high-fat diet intake. The ABP had a greater protective effect on the healthy liver compared to fenofibrate treatment due to its bioactive compound content.