Details

Autor(en) / Beteiligte

• Sun, Chengyi
• Xiong, Zhiyi
• Sun, Chongyang
• Liu, Tinglan
• Liu, Xiaoyu
• Zhang, Qinhong
• Liu, Baoyan
• Yan, Shiyan
• Liu, Cunzhi

Titel

Placebo response in sham-acupuncture–controlled trials for migraine: A systematic review and meta-analysis

Ist Teil von

• Complementary therapies in clinical practice, 2023-11, Vol.53, p.101800-101800, Article 101800

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To understand the placebo response of acupuncture and its effect on migraine and optimize the design of future acupuncture clinical trials on migraine treatment. Randomized controlled trials with sham acupuncture as a control in migraine treatment were searched in four English databases from inception to September 1, 2022. The primary outcome was placebo response rate. Secondary outcomes were migraine symptoms, emotional condition, and quality of life. Factors associated with placebo response were also explored. Results were combined using risk difference (RD) or standardized mean difference (SMD) and 95% confidence interval (CI) with a random effects model. The final analysis included 21 studies involving 1177 patients. The pooled response rate of sham acupuncture was 0.34 (RD, 95% CI 0.23–0.45, I2 89.8%). The results (SMD [95% CI]) showed significant improvements in migraine symptoms (pain intensity −0.56 [−0.73 to −0.38], and episode conditions −0.55 [−0.75 to −0.35]); emotional condition (anxiety scale −0.49 [−0.90 to −0.08] and depression scale −0.21 [−0.40 to −0.03]); and quality of life on the Migraine-Specific Quality-of-Life Questionnaire (restrictive 0.78 [0.61–0.95]; preventive 0.52 [0.35–0.68]; and emotional 0.45 [0.28–0.62]) and on the Medical Outcomes Study Short-Form (physical 0.48 [0.34–0.62] and mental 0.21 [0.02–0.41]). Only acupuncture treatment frequency had a significant impact on the placebo response rate (RD 0.49 vs. 0.14; p = 0.00). The effect sizes for placebo response of sham acupuncture varied across migraine treatment trials. Further studies should routinely consider adjusting for a more complete set of treatment factors. •Placebo response of sham acupuncture were notable but vary in different outcomes.•Treatment frequency may affect placebo response of sham acupuncture in migraine.•Placebo response of sham acupuncture may be long lasting during the follow-up period.