Details

Autor(en) / Beteiligte

• Calò, Leonardo
• Crescenzi, Cinzia
• Martino, Annamaria
• Casella, Michela
• Romeo, Fabiana
• Cappelletto, Chiara
• Bressi, Edoardo
• Panattoni, Germana
• Stolfo, Davide
• Targetti, Mattia
• Toso, Elisabetta
• Musumeci, Maria Beatrice
• Tini, Giacomo
• Ciabatti, Michele
• Stefanini, Matteo
• Silvetti, Elisa
• Stazi, Alessandra
• Danza, Maria Ludovica
• Rebecchi, Marco
• Canestrelli, Stefano
• Fedele, Elisa
• Lanzillo, Chiara
• Fusco, Armando
• Sangiuolo, Federica Carla
• Oliviero, Giada
• Radesich, Cinzia
• Perotto, Maria
• Pieroni, Maurizio
• Golia, Paolo
• Mango, Ruggiero
• Gasperetti, Alessio
• Autore, Camillo
• Merlo, Marco
• de Ruvo, Ermenegildo
• Russo, Antonio Dello
• Olivotto, Iacopo
• Sinagra, Gianfranco
• Gaita, Fiorenzo

Titel

The Diagnostic Value of the 12-Lead ECG in Arrhythmogenic Left Ventricular Cardiomyopathy: Novel ECG Signs

Ist Teil von

• JACC. Clinical electrophysiology, 2023-12, Vol.9 (12), p.2615-2627

Ort / Verlag

United States

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Electrocardiographic (ECG) findings in arrhythmogenic left ventricular cardiomyopathy (ALVC) are limited to small case series. This study aimed to analyze the ECG characteristics of ALVC patients and to correlate ECG with cardiac magnetic resonance and genotype data. We reviewed data of 54 consecutive ALVC patients (32 men, age 39 ± 15 years) and compared them with 84 healthy controls with normal cardiac magnetic resonance. T-wave inversion was often noted (57.4%), particularly in the inferior and lateral leads. Low QRS voltages in limb leads were observed in 22.2% of patients. The following novel ECG findings were identified: left posterior fascicular block (LPFB) (20.4%), pathological Q waves (33.3%), and a prominent R-wave in V with a R/S ratio ≥0.5 (24.1%). The QRS voltages were lower in ALVC compared with controls, particularly in lead I and II. At receiver-operating characteristic analysis, the sum of the R-wave in I to II ≤8 mm (AUC: 0.909; P < 0.0001) and S-wave in V plus R-wave in V  ≤12 mm (AUC: 0.784; P < 0.0001) effectively discriminated ALVC patients from controls. It is noteworthy that 4 of the 8 patients with an apparently normal ECG were recognized by these new signs. Transmural late gadolinium enhancement was associated to LPFB, a R/S ratio ≥0.5 in V , and inferolateral T-wave inversion, and a ringlike pattern correlated to fragmented QRS, SV +RV  ≤12 mm, low QRS voltage, and desmoplakin alterations. Pathological Q waves, LPFB, and a prominent R-wave in V were common ECG signs in ALVC. An R-wave sum in I to II ≤8 mm and SV +RV  ≤12 mm were specific findings for ALVC phenotypes compared with controls.