Details

Autor(en) / Beteiligte

• Li, Yanni
• Han, Yujia
• Li, Hongxia
• Niu, Xiaohui
• Zhang, Deyi
• Wang, Kunjie

Titel

Antimicrobial Hydrogels: Potential Materials for Medical Application

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2024-02, Vol.20 (5), p.e2304047-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

Access via Wiley Online Library

Beschreibungen/Notizen

• Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from trauma worldwide. The prevalence of drug‐resistant pathogens has led to a significant increase in medical costs and poses a great threat to the normal life of people. This is an important issue in the field of biomedicine, and the emergence of new antimicrobial materials hydrogels holds great promise for solving this problem. Hydrogel is an important material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, and controlled release of drugs as well as structural diversity. Bacteria‐disturbing hydrogels have important applications in the direction of surgical treatment, wound dressing, medical device coating, and tissue engineering. This paper reviews the classification of antimicrobial hydrogels, the current status of research, and the potential of antimicrobial hydrogels for one application in biomedicine, and analyzes the current research of hydrogels in biomedical applications from five aspects: metal‐loaded hydrogels, drug‐loaded hydrogels, carbon‐material‐loaded hydrogels, hydrogels with fixed antimicrobial activity and biological antimicrobial hydrogels, and provides an outlook on the high antimicrobial activity, biodegradability, biocompatibility, injectability, clinical applicability and future development prospects of hydrogels in this field. Antibacterial hydrogels generally kill bacteria by disrupting cellular material transport, intracellular proteins, cell walls, reactive oxygen species and DNA. Due to the different properties of antimicrobial hydrogels of different compositions, their fields of application have expanded considerably. This also shows their great potential for biomedical applications